METHYL 3,4-DIMETHOXYPHENYL ACETATE
Methyl 3,4-Dimethoxyphenyl Acetate
CAS: 15964-79-1
Molecular Formula: C11H14O4
METHYL 3,4-DIMETHOXYPHENYL ACETATE - Names and Identifiers
METHYL 3,4-DIMETHOXYPHENYL ACETATE - Physico-chemical Properties
| Molecular Formula | C11H14O4 |
| Molar Mass | 210.23 |
| Density | 1.105±0.06 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 175℃ (15 Torr) |
| Flash Point | 121.6±23.2℃ |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Oil |
| Color | Colourless |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5253 (23℃) |
METHYL 3,4-DIMETHOXYPHENYL ACETATE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Application | 3, 4-dimethoxyphenylacetate methyl ester, also known as high veratryl acid methyl ester, can be used to synthesize β-receptor blocker bevanolol (bevantolol) and antiarrhythmic drug verapamil (verapamil), etc., are also key intermediates for the synthesis of isoquinoline alkaloids. |
| preparation | 250ml three-neck bottle was added with ethyl 3, 4-dimethoxyacetophenone (17.9g,0.075mol), ethylene glycol (60ml) and 85% hydrazine hydrate (22.1g,0.375mol), slowly heated to 120 ℃ for 2h. After cooling to room temperature, add potassium hydroxide (12.6g,0.225mol), heat to 180 ℃, evaporate low boiling matter (about 2h) while heating, and then reflow for 4h. After the reaction, cool to room temperature, add 6mol/L hydrochloric acid (about 30ml) to pH2 ~ 3. Add water (150ml), extract with ethyl acetate (50ml × 4), and combine the organic phase. After washing with water (50ml × 2), it is dried by anhydrous sodium sulfate and then filtered, the filtrate is concentrated to dry under reduced pressure, and the remainder is recrystallized with ethyl acetate-petroleum ether (1:1) to obtain a white solid 3, 4-dimethoxyphenylacetic acid (10.8g,73.4%). 3, 4-dimethoxyphenylacetic acid and methanol esterification condensation, the target product 3, 4-dimethoxyphenylacetate methyl ester. |
| biological activity | Methyl homoveratrate is a RWJ-26240 metabolite in vivo and can be detected in plasma, urine and feces. McN5691 (RWJ-26240) is a voltage-dependent calcium channel (calcium channel) blocker. |
Last Update：2024-04-09 20:52:54
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